Tottenham threw away a 2-1 lead as Wolves hit back to 3-2 thanks to second half goals from Diogo Jota and Jimenez. Wolves are now moved two points above Tottenham into sixth place in the Premier League.
As it stands, finishing fifth could lead to a Champions League place, owing to second placed Manchester City’s European ban, against which they are appealing.
Sitting level on points with fifth placed Manchester United and just three behind fourth placed Chelsea, Wolves are firmly in the hunt for an unexpected berth in Europe’s elite club competition
They fell behind to Steven Bergwijn’s first half opener, but Matt Doherty equalised and even Serge Aurier restoring Tottenham’s lead couldn’t knock Wolves out of their stride.
It was a bitter blow for injury-hit Tottenham, who suffered three consecutive defeats in all competitions for the first time this season.
Heading into this weekend, Spurs had kept just three clean-sheets in 22 games in all competitions since Mourinho took charge.
So Mourinho dropped defenders Toby Alderweireld and Jan Vertonghen as part of four changes following last week’s defeat at Chelsea, with keeper Hugo Lloris sidelined by a groin injury.
Those switches included midfielder Eric Dier dropping back to centre-half and exploited Mourinho’s reshuffle time and again.
Tottenham had their chances and took the lead with a superb counter in the 13th minute.
Giovani Lo Celso picked out Aurier’s run down the right and when the right-back’s cross reached Dele Alli, his shot was pushed out by Rui Patricio into the path of Bergwijn, who slotted home from close-range.
It was the Dutch winger’s second goal since joining Tottenham from PSV Eindhoven in January.
But the hosts remained creaky at the back and Nuno’s men crafted an impressive equaliser in the 27th minute.
Ruben Vinagre ran onto Jota’s pass and fought his way past Aurier to the touchline, where he delivered a teasing cross into the six-yard box.
Dier and Japhet Tanganga both made a hash of attempting to clear and Doherty made them pay as the defender fired past Paulo Gazzaniga for his seventh goal of the season.