Coach Maurizio Sarri has opted to rest the forward with Juventus playing Lyon in the Champions League last 16 on February 26. Ronaldo, 35, has scored in ten consecutive Serie A games,
However Captain Chiellini is set to return after rupturing cruciate ligaments in the right knee at the end of August.
The 35-year-old has been training again with the eight-time reigning champions and was on Saturday named in the squad to play Brescia in Turin.
His presence should provide a boost for Juventus who have lost top spot in Serie A to Inter Milan on goal difference and suffered two defeats in their last three games.